This report presents a global analysis of the different effects of short and long 3′ UTRs on mRNA decay and translation. 3′ UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts. Upf1 senses 3′ UTR length to potentiate mRNA decay.
lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements. Three functional variants of IFN regulatory factor 5 ( IRF5) define risk and protective haplotypes for human lupus. 3′ UTR shortening potentiates microRNA-based repression of pro-differentiation genes in proliferating human cells. Global analyses of the effect of different cellular contexts on microRNA targeting. This publication reports a connection between 3′ UTR shortening, especially in the transcripts of several proto-oncogenes, and cell transformation. Widespread shortening of 3′ UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. This article describes global APA regulation in embryonic development, connecting polyadenylation activity with APA during cell differentiation. Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. This is the first report that global changes in APA occur as a consequence of changes in cell proliferation, specifically demonstrating the use of proximal 3′ UTR PASs during the activation of T cells. Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites. MicroRNAs: target recognition and regulatory functions. Messenger RNA 3′ end formation in plants. Alternative cleavage and polyadenylation: the long and short of it. Mechanisms and consequences of alternative polyadenylation. Alternative cleavage and polyadenylation: extent, regulation and function. Ending the message: poly(A) signals then and now. Evolution and biological roles of alternative 3′ UTRs. Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing. A quantitative atlas of polyadenylation in five mammals. A large-scale analysis of mRNA polyadenylation of human and mouse genes. This paper reports the first use of expressed sequence tags to identify APA sites genome-wide. Alternate polyadenylation in human mRNAs: a large-scale analysis by EST clustering. Gautheret, D., Poirot, O., Lopez, F., Audic, S. Last but not least: regulated poly(A) tail formation.
Alternative poly(A) site selection in complex transcription units: means to an end? Nucleic Acids Res. Mechanism and regulation of mRNA polyadenylation.
The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site. Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Protein factors in pre-mRNA 3′-end processing. Signals for pre-mRNA cleavage and polyadenylation. Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Transcription termination by nuclear RNA polymerases.
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